Because initiating animal research at the University of California (UC), Berkeley can feel overwhelming as a new investigator coming to campus, the information below provides basic information of where to start the process!

The first step to using animals in research or classes is submitting an Animal Use Protocol (AUP) and getting it approved by the Animal Care and Use Committee (ACUC).

Before submitting your AUP:

  • Discuss the following with the Office of Laboratory Animal Care (OLAC) veterinarians:
    • Your procedures and projects using animals
    • Animal acquisition, purchase, transport and quarantine procedures
    • Availability of housing and procedure space
    • Access to the animal facilities
  • Contact the Office of Environment, Health & Safety (EH&S) to:
    • Discuss using hazardous agents, chemicals, toxic gas, controlled substances, radioisotopes, ionizing and non-ionizing radiation-producing sources/machines, lasers, etc. in your animal research
    • Complete and submit the appropriate forms, e.g., Biological Use Authorizations (BUAs), Radiation Use Authorization (RUAs) (required prior to ACUC approval)
    • Obtain approval by the appropriate EH&S committees or individuals to use these drugs, compounds, machines, etc.
    • Find out about laboratory safety requirements and training.
  • Contact the Stem Cell Research Oversight (SCRO) Committee:
    • If you plan to use human embryonic or adult stem cells
    • Submit a Stem Cell Research Protocol application and obtain SCRO Committee approval prior to initiating any human embryonic or adult stem cell research.

Preparing your AUP:

  • ACUC launched an on-line protocol submission and review program in July 2014 called eProtocol. This is the same system the UCB Office for Protection of Human Subjects (OPHS) has used since 2009.
  • To find out more about submitting an AUP in eProtocol, visit the ACUC eProtocol Instructions.
  • Visit the ACUC website to view UC Berkeley’s animal policies and guidelines, understand the review process, download eProtocol Quick Guides for Investigators, and view the submission deadline calendar.
  • If you have any questions on how to complete and submit the AUP in eProtocol:
  • If you are teaching a class involving animals
    • Request a copy of the Ethics in Animal Research presentation and the handout outlining health and safety information when working with animals for your students
  • All individuals listed on a an AUP are required to complete:
  • Submit your AUP via the online eProtocol system by the appropriate submission deadline
  • Answer the reviewers’ and/or committee’s questions
  • Once approved, you will receive the approval letter from the ACUC/OACU

After your AUP is approved by the ACUC:

  • Request ACUC inspection of your space
  • Contact the OACU if you have received positive feedback from the funding agency regarding funding
  • Register for use of controlled substances with EH&S once approved by the ACUC for their use in animals
  • Remember: No changes in animal numbers, species, personnel or animal use procedures may be made without prior review and approval by the ACUC. Proposed changes must be submitted in the form of an amendment to your protocol and be approved by the ACUC before being undertaken.

Please download our Quick Guide to Animal Research for basic information about the relevant offices and services that are available on campus to help you in your research!